|Flying Spaghetti Monster|
In this section we will again just look at very small slice of evidence: Understanding the mechanisms of insulin resistance and how it relates to glucose intolerance, high fasting glucose, and fatty acid disruption.
-->The Actions of Insulin and Insulin resistance
Lets first begin this discussion with a quick history lesson. Insulin appears to be have been first discovered back in 1916 by Sir Edward Schafer. He wrote in his book, The Endocrine Organs :
"The results of pancreas extirpation and pancreas grafting are best explained by supposing that the islet tissue produce an Autacoid which passes into the blood stream and effects carbohydrate metabolism and carbohydrate storage in such a manner that there is no undue accumulation of glucose in the blood. provisionally it will be convient to refer to this hypothetical substance as insuline."-(41)
Insulin was officially discovered 8 years later in 1921 and Schafer also hypothesized that insulin was created by an inactive precursor which was also discovered 50 years later and is known today as??/ that's right.. Pro- Insulin. Schafer was truly a man ahead of his time...